Big Pharma has been doggedly searching for drugs that target a group of nuclear receptor proteins in the human body known by the long title of peroxisome proliferator-activated receptors (PPARs, for short). The reason? PPARs regulate the expression of genes that are involved in fat and carbohydrate metabolism, among other functions -- so the theory is that if drugs could control PPARs, the medications would treat diabetes, high cholesterol and even maybe obesity.
But it turns out there's already a substance that could do all this. And it's not a side effect-laden chemical. It's a compound in grapefruit. Read more...
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